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piątek, 8 kwietnia 2016

Transfuzja krwi - Borelioza

TRANSFUZJE NAJEŻONE NIEBEZPIECZEŃSTWAMI

Choroba przeniesiona przez krew niepokoi sumiennych lekarzy i martwi wielu pacjentów. Jaka choroba? Prawdę mówiąc, nie chodzi tylko o jedną, bo jest ich naprawdę dużo. Po omówieniu bardziej znanych podręcznik Techniques of Blood Transfusion (1982 ) wymienia „inne choroby zakaźne związane z transfuzją”, w rym również kiłę, zakażenie wirusem cytomegalii i malarię.

Następnie czytamy:

 „Doniesiono też o przenoszeniu przez transfuzję szeregu innych chorób, takich jak zakażenie wirusem opryszczki, mononukleoza zakaźna (wirus Epsteina-Barra), toksoplazmoza, trypanosomatozy [śpiączka afrykańska i choroba Chagasa], leiszmanioza [czarna febra], bruceloza, dur plamisty, filarioza, odra, salmonelloza oraz gorączka kleszczowa z Kolorado”.

W gruncie rzeczy powyższa lista wciąż się wydłuża.

Może na przykład spotkałeś takie nagłówki: „Choroba Lyme'a z transfuzji? Mało prawdopodobna, ale specjaliści są ostrożni”. Jak bezpieczna jest krew od kogoś, u kogo testy wykazały chorobę Lyme'a? Grupę ekspertów ze służby zdrowia zapytano, czy pozwoliliby ja sobie przetoczyć. „Wszyscy zgodnie odpowiedzieli, że nie, chociaż żaden nie zalecił wyeliminowania krwi pochodzącej od takich dawców”.

Jak społeczeństwo ma się zapatrywać na przechowywaną w bankach krew, której specjaliści by nie przyjęli? (The New York Times z 18 lipca 1989). Kolejny powód do niepokoju to okoliczność, że krew pobrana w kraju, w którym pewne choroby są bardzo rozpowszechnione, może być użyta zupełnie gdzie indziej, gdzie ani opinia publiczna, ani lekarze nie są świadomi kryjącego się w niej niebezpieczeństwa. Przy dzisiejszym rozwoju turystyki oraz w związku z ruchem uchodźców i imigrantów, ciągle wzrasta ryzyko, że w takim czy innym preparacie krwiopochodnym kryje się jakaś dziwna choroba.

Co więcej, pewien specjalista chorób zakaźnych ostrzegł: „Może zajść potrzeba przetestowania zasobów krwi, aby zapobiec przenoszeniu szeregu schorzeń, których dawniej nie uważano za zakaźne, na przykład białaczki, chłoniaka i otępienia przedstarczego [czyli choroby Alzheimera]” (Transfusion Medicine Reviews ze stycznia 1989). Już te niebezpieczeństwa przejmują dreszczem, ale dalsze budzą dużo większy postrach…

http://neurolingwistyka.com/gmo/57-naukowe-fanaberie/353-52transfuzja-krwi-niebezpieczna

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Abstract

Lyme disease (or Lyme borreliosis) is caused by a spirochetal bacteria, Borrelia burgdorferi. Increased recognition of the disease and increased exposure to the vector (ticks) capable of spreading B. burgdorferi from animal hosts have resulted in a rise in the number of cases of Lyme borreliosis reported in the United States. There are three stages of the clinical course of Lyme borreliosis; however, not all those infected will have typical manifestations of each stage, such as the arthritis of the third stage. Routine blood cultures will rarely document bacteremia and serologic testing is not yet reliable. Early treatment can prevent later stages of Lyme borreliosis. There is evidence that transmission of B. burgdorferi by blood transfusion is possible, but, to date, there has been no documentation of transfusion-associated Lyme borreliosis. Thus, no new recommendations for screening donors to identify possible carriers of B. burgdorferi are suggested at this time

http://www.ncbi.nlm.nih.gov/pubmed/2672435

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Abstract

BACKGROUND:

Borrelia miyamotoi, a recently discovered relapsing fever spirochete, occurs in hard-bodied ticks wherever Lyme disease is endemic. Human infection is associated with relapsing fever and can cause meningoencephalitis in immunocompromised patients. A few cases of transfusion transmission of other relapsing fever spirochete species have been reported but none for B. miyamotoi. Our objective was to determine whether B. miyamotoi transfusion transmission could occur in a murine transfusion model. Herein, we report transfusion transmission of B. miyamotoi through fresh or stored red blood cells (RBCs) in a mouse model.

STUDY DESIGN AND METHODS:

Inbred mice were transfused with B. miyamotoi-infected murine blood that was either freshly collected or stored for 7 days before transfusion. Recipient blood was then longitudinally examined after transfusion by smear and wet mount for evidence of spirochetemia.

RESULTS:

Motile spirochetes were observed in immunocompromised (SCID) mouse recipients for 28 days after transfusion of both fresh and stored murine B. miyamotoi-infected RBCs. Transient spirochetemia was observed in immunocompetent DBA/2 and C57BL/6 mice, with spirochete clearance occurring within 5 days after transfusion.

CONCLUSION:

These data demonstrate that transfusion transmission of B. miyamotoi can occur in mice and suggest that it also may occur in humans.

http://www.ncbi.nlm.nih.gov/pubmed/25251880

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The risk of acquiring Lyme disease or babesiosis from a blood transfusion.Gerber MA1, Shapiro ED, Krause PJ, Cable RG, Badon SJ, Ryan RW.
 
Abstract
To determine the risk of acquiring Lyme disease or babesiosis from blood transfusion, serum was collected before and 6 weeks after patients received multiple transfusions during cardiothoracic surgery and antibodies to Borrelia burgdorferi and Babesia microti were measured. Of 155 subjects, 149 received 601 total units of packed red blood cells (PRBC) and 48 received 371 total units of platelets. No patient developed clinical or serologic evidence of Lyme disease; 1 (who received 5 units of PRBC) developed clinical and serologic evidence of babesiosis. The risk of acquiring Lyme disease from a transfused unit of PRBC was 0 (95% confidence interval [CI], 0-0.5%) and from a transfused unit of platelets was 0 (95% CI, 0-0.8%); the same risks for babesiosis were 0.17% (95% CI, 0.004%-0.9%) and 0 (95% CI, 0-0.8%), respectively. The risk of acquiring either Lyme disease or babesiosis from a blood transfusion in Connecticut is very low


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Abstract:
 
Hematogenous dissemination of organisms occurs in many spirochetal diseases, including Lyme disease and syphilis. Although syphilis has been transmitted by transfusion, in the vast majority of cases, only fresh blood products were involved, in part because Treponema pallidum survives poorly when refrigerated in citrated blood. Because of the rising incidence of Lyme disease in certain areas, whether its causative agent, Borrelia burgdorferi, could survive under blood banking conditions was studied. Dilutions of stock cultures of two strains of B. burgdorferi were inoculated into samples of citrated red cells (RBCs). Viable spirochetes were recovered from RBCs inoculated with 10(6) organisms per mL, after refrigeration for as long as 6 weeks. It is concluded that B. burgdorferi may survive storage under blood banking conditions and that transfusion-related Lyme disease is theoretically possible


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At this point the best we may get is a compromise of screening blood donations from the five states where the incidence of babesiosis is highest—Connecticut, Massachusetts, New Jersey, New York, and Rhode Island. The FDA estimates this will reduce the risk of transfusion-transmitted Babesia microti in the blood supply by 95%. However, this will do nothing to mitigate the risk of contracting other species of Babesia.
 
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They found that after analyzing 89,153 blood samples, 335, or 0.38%, were positive for babesiosis, and these donations were removed from the blood supply. During the study period, which was from June 2012 to September 2014, there were 29 recorded cases of transfusion-acquired babesiosis. These came from blood that was not screened, and follow-up of the specific donor samples showed later that the source blood tested positive for Babesia.
When focused on Connecticut and Massachusetts, the researchers found that for screened blood, there were no transfusion-transmitted babesiosis cases in 75,331 blood donations. In contrast, with unscreened blood, there were 14 cases of babesiosis in 253,031 donations. This showed that blood donation screening was effective in preventing babesiosis transmission via blood transfusion.
Every year, about 1800 cases of babesiosis are reported to public health authorities, with 95% of cases in only 7 states. However, this is likely to be an undercount, due to low medical awareness and misdiagnosis of the disease. Presently, there is no Babesia blood donation screening test that has been approved by the Food and Drug Administration. This study and others like it will hopefully lead to such a test, by showing the vital importance of protecting our blood supply from a dangerous pathogen.
 
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2. Donated blood and body tissue
 
Donation of blood, bone marrow, organs or other tissues transmits pathogens between donor and recipient – even, in the case of blood donation, when there is an attempt to filter blood. At an average of around 0.01 microns in diameter, L-form (!) bacteria are small enough to pass through even the finest of filters:
 
3. Survival of Borrelia burgdorferi in blood products (Badon SJ, Fister RD, Cable RG}:
The organism was shown to survive in RBCs (4 degrees C) and FFP (below -18 degrees C) for 45 days and in PCs (20-24 degrees C) for 6 days. The results of this study do not exclude the possibility of transmission of Lyme disease through blood transfusion. http://www.ncbi.nlm.nih.gov/pubmed/2773025
 
4. Transfer of Borrelia burgdorferi s.s. infection via blood transfusion in a murine model (Gabitzsch ES, Piesman J, Dolan MC, Sykes CM, Zeidner NS):
Our results indicate that it is possible to acquire B. burgdoferi infection via transfused blood in a mouse model of Lyme borreliosis.
 
Nine of 19 (47.7%) immunodeficient mice, 7 of 15 (46.8%) inbred immunocompetent mice, and 6 of 10 (60.0%) outbred mice became infected with B. burgdorferi after transfusion. Our results indicate that it is possible to acquire B. burgdoferi infection via transfused blood in a mouse model of Lyme borreliosis.
 
5. The data demonstrate that B. burgdorferi can survive the blood processing procedures normally applied to transfused blood in the USA:
 
6. These data demonstrate that transfusion transmission of B. miyamotoi can occur in mice and suggest that it also may occur in humans:
 
7. According to a study of Nohlmans in 1991, 9% of infected blood preserved in the Netherlands. However, the epidemiological significance of these findings have not been investigated to date. Nadelman showed that the bacterium Borrelia was still present after six weeks of refrigerated storage of preserved blood, and that a is theoretically possible to Lyme disease-related transfusion. Several other studies have come to the same conclusion.
 
8. Even more tests:
 
9. Dr. Tang adds other avenues of infection: “Transmission may also occur via blood transfusion and through the bite of mosquitoes or other insects.” Dr. Cowden contends that unpasteurized goat or cow milk can infect a person with Bb.
 
10. The results of this study do not exclude the possibility of transmission of Lyme disease through blood transfusion.
 
11. US studies have found Borrelia “may survive storage under blood banking conditions and that transfusion-related Lyme disease is theoretically possible”
Nadelman RB, Sherer C, Mack L, Pavia CS & Wormser GP. 1990, Survival of Borrelia burgdorferi in human blood stored under blood banking conditions: http://www.ncbi.nlm.nih.gov/pubmed/2349627
 
12. An article raising concerns about the transfusion-based transfusion was published. http://annals.org/article.aspx?articleid=475003%20
 
13. A study conducted at the Sacramento (California) Medical Foundation Blood Center in 1989 states that there is evidence that the transmission of Borrelia is possible by blood transfusion. http://www.samento.com.ec/nutranews/story005.html
 
14. Furthermore, in 1990, a study by the Centers for Disease Control (CDC) in Atlanta, Georgia stated that the data demonstrates that Borrelia burgdorferi can survive the blood processing procedures normally applied to transfused blood in the USA. http://www.samento.com.ec/sciencelib/4lyme/bbinfectedhuman.htm
 
15. In January, the CDC recommended that public health departments report all cases of the infections to curb risks of infection via transfusion.
 
Also because of the many misdiagnoses, it is the safest to not donate blood. Vanessa was found that after 25 years of missing diagnoses Lyme and co infections. She had given blood several times and likely infected people like you in the evidence may have read above. Lyme disease is often discovered only after decades due to poor testing in the Netherlands. These are only 30% reliable with the result that patients walking around with missing diagnoses such as MS, ALS, Fibromyalgia, CFS/ME, rheumatoid arthritis, ADHD, ADD.
“I’ve been very concerned about this issue and have spoken to Canadian Blood Services about it. I was very disappointed with their lack of knowledge and slowness to put measures into place to protect the public. I have given blood several times since I got Lyme, Bartonella and Mycoplasma because I was told it was ‘some kind of arthritis’ for over 25 years!” http://www.lymediseasebook.com/lyme_disease_risk_to_the_blood_supply
 
 
18. Karen Smith, 51, from Northern Ireland, told the Sunday Telegraph she believes she may have contracted Lyme disease after undergoing a blood transfusion in 1987 while giving birth to her first child and may have passed it on to her children. http://www.telegraph.co.uk/news/health/news/11924482/Lyme-disease-cases-have-quadrupled.html
 
Borrelia arthritis after transplantation:
An incident of Borrelia arthritis after autologous chondrocyte transplantation for the repair of a cartilage defect.
 
Transmission is a key point inasmuch as millions of people world-wide are affected by blood, blood and tissue products and other human biologicals that indeed have the tremendous potential to transmit these important infections. I have an anecdotal case history of a woman who donated a kidney to her sister. The donor had been treated for Lyme disease. The recipient had no known history of Lyme disease. Both were sisters who lived in different countries—one in the US, the other in Germany. The result was the recipient succumbed to Lyme disease, which, due to her immunosuppressive drugs to ward off tissue rejection, took hold of her within a short time period following transplant surgery, and she died of Lyme infection.


Borrelia DNA in earwax:
Artikel uit 1994:
In a female patient with increasing redness of the hands and face, proteins of Borrelia burgdorferi were detected in a biopsy of the ear by DNA amplification. Although acrodermatitis chronica atrophicans has been documented to be caused by B. burgdorferi, this is the first case with proven spirochetal presence in the skin of the head. After 2 weeks of intravenous therapy with ceftriaxone marked improvement of discoloration of the skin was noted. http://www.ncbi.nlm.nih.gov/pubmed/7873838
 
Transmission by insects such as horseflies, mosquitoes, spiders, mites, fleas:
 
The World Health Organisation reports: More than half the world’s population is at risk from diseases such as malaria, dengue, leishmaniasis, Lyme disease, schistosomiasis, and yellow fever, carried by mosquitoes, flies, ticks, water snails and other vectors. Every year, more than one billion people are infected and more than one million die from vector-borne diseases.  Read more…
1. According to Dr. Dietrich Klinghardt, one of the leading authorities on Lyme disease, the bacteria can also be spread by other insects, including mosquitoes, spiders, fleas, and mites: http://articles.mercola.com/sites/articles/archive/2012/10/13/under-our-skin-documentary.aspx
Dr. Klinghardt of ILADS says that the bacterium is transmitted by mosquitoes, spiders, flies, and mites.
 
2. On July 10, 1989, while jogging with no shirt on, a 42-year-old man from Old Lyme, Connecticut, an area in which Lyme disease is endemic, was bothered by a large fly that he believed to be either a deerfly or a horsefly. After swatting at it unsuccessfully, he was bitten by the fly several times on the right side of the chest. The bites were acutely painful. The area around the bites was swollen for one to two days; the swelling then subsided.
This patient was bitten by a biting fly (an act he both saw and felt) and subsequently presented with Lyme disease, with erythema migrans at the site of the bite. http://www.nejm.org/doi/full/10.1056/NEJM199006143222415
 
There are many patients like the story above that can confirm that they had a bulls-eye (the famous red circle) after the bite of a gadfly.
 
3 Clear article:
It is not a rare disease, it is epidemic. It is not just tick-borne; it can also be transmitted by other insects, including fleas, mosquitoes and mites — and by human-to-human contact: http://articles.mercola.com/sites/articles/archive/2001/07/25/lyme-disease-part-two.aspx
 
4 Dr Steven Luger reported in The New England Journal of Medicine a case in which a patient was bitten by a large fly and presented 13 days later with Lyme symptoms. These were resolved via pharmaceutical treatment.
 
5 A German study of patients with Lyme arthritis identified evidence, through serological test for antibodies to the causative spirochete, that one patient had contracted the disease from a fly.‘Lyme arthritis: Clinical features, serological and radiographic findings of cases in Herzer P, Wilske B, Preac-Mursic V, G Schierz, Schattenkirchner M, & Zollner N. 1986, Lyme Arthritis: Clinical Features, Serological, and Radiographic Findings of Cases in Germany, Klinische Wochenschrift 64:206-215.

6 A French study of four Lyme patients ascertained that only one was bitten by a tick; the researchers suggested that two of the patients may have contracted the disease from a mosquito or biting fly. Doby JM, Chastel C, Couatarmanac’h A, Cousanca C, Chevrant-Breton J, Martin A, Legay B & Guiquen C. 1985, Etiologic and epidemiologic questions posed by erythema chronicum migrans and Lyme disease, Bull Soc Pathol Exot Filiales 78(4):512-525.

7 Borrelia burgdorferi was identified in 13 species of mites, 15 species of flies and two species fleas. Pokornỳ P. 1989, Incidence of the spirochete Borrelia burgdorferi in arthopods (Arthropoda) and antibodies in vertebrates (Vertebrata), Cesk Epidemiol Mikrobiol Imunol. 38(1):52-60.

8 A study identified Borrelia spirochetes in mosquitoes and fleas. Hubálek Z, Halouzka J & Juřicová Z. 1998, Investigation of haematophagous arthropods for borreliae – summarised data 1988-1996, Folia Parasitologica 45: 67-72.

9 Borrelia burgdorferi spirochetes identifiedin mosquitoes and flies. Magnarelli LA & Anderson JF. 1988, Tick and biting insects infected with the etiologic agent of Lyme disease, Borrelia burgdorferi, J. Clin. Microbiol. 26(8):1482.

10 Borrelia afzelii spirochetes identified in female mosquitoes of the genus Culex, Aedes and Anopheles.Zákovská A, Capková L, Serỳ O, Halouzka J & Dendis M. 2006,Isolation of Borrelia afzelii from Overwintering Culex Pipiens Biotype Molestus Mosquitoes, Ann Agric Environ Med. 13(2):345-348. Alle onderzoeken zijn hier terug te vinden:
http://www.lymedisease.org.au/transmission/

11 Wetenschappelijke studie die aantoont dat de Borrelia-bacterie ook wordt aangetroffen in Duitse muggen:
http://www.sciencedirect.com/science/article/pii/S1877959X15300327

12    Forty-eight Lipoptena cervi were collected from southwestern Pennsylvania. There were 19 (39.58%) deer keds positive for Borrelia burgdorferi and 14 (29.12%) deer keds positive for Anaplasma phagocytophlyum. Out of the 48 deer ked, three (6.25%) were co-infected with the etiologic agents of Lyme disease and anaplasmosis. http://onlinelibrary.wiley.com/doi/10.1111/jvec.12225/pdf

So no, you do not need to be bitten by a tick to get Lyme disease. A bit of a gadfly, mosquito, mite and flea occurs regularly. You can be a carrier of the bacterium without knowing it.
How sick or ill you’ll get has to do with the amount of bacteria, how long they are already present in your body / grow, how strong the immune system is, how well you’re able to detox and the amount of stress in your life.

https://www.lymeepidemie.nl/transfer-lyme-disease/?lang=en
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Other infections

Along with the tests noted above, all blood for transfusion is tested for syphilis, as well as HTLV-I and HTLV-II (viruses linked to human T-cell leukemia/lymphoma). Since 2003, donated blood has been tested for the West Nile virus, too. In 2007, blood banks also began testing for Chagas disease (common in South and Central America).
Diseases caused by certain bacteria, viruses, and parasites, such as babesiosis, malaria, Lyme disease, and others can also be spread by blood product transfusions. But because potential donors are screened with questions about their health status and travel, such cases are very rare.

https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/blood-transfusion-and-donation/how-blood-transfusions-are-done.html
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