P41 w boreliozie

,, Our results show that 2.6% of the sera submitted for B. burgdorferi serology expressed anti-p41 IgM but not IgG antibodies. Because 84% of these anti-p41 IgM positive sera came from patients in which a B. burgdorferi infection was unlikely, most of the results should be classified as diagnostically false positive for these patients. Only 16% of the sera with anti-p41 IgM antibodies came from patients with likely B. burgdorferi infection. Notably, none of the sera from the patients with recent erythema migrans were positive in the IgM immunoblot. It is not clear why the patients with erythema migrans did not develop IgG anti-p41 antibodies or antibodies against other borrelia antigens on immunoblots. However, all these patients had been treated with penicillin early during infection. This may have reduced the antigenic load and thereby prevented the natural development of the immune reaction [9]. ,,

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-3083.2001.00893.x

,,Collins and Peltz (6) studied 15 serum specimens, including 5 from our area in which Lyme borreliosis is endemic, and found that all bound recombinanthis is consistent with the fact that the IgM response to p41 occurs prior to the IgG response in early Lyme disease (5, 7). ,,

https://jcm.asm.org/content/jcm/30/6/1535.full.pdf

P41

Wewnętrzna część flagelliny

Wysoce swoisty antygen wczesnej odpowiedzi przeciwciał

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000300807


https://onlinelibrary.wiley.com/doi/pdf/10.1002/1529-0131%28199912%2942%3A12%3C2705%3A%3AAID-ANR29%3E3.0.CO%3B2-H