Bartonella może zarażać narządy i tkanki w całym organizmie
Bartonella jest zakażeniem bakteryjnym Gram-ujemne bakterie które mogą być przenoszone przez owady, pchły, wszy, moskity [1], odchody pcheł, [2] roztocza [3], przez kleszcze [4], pająki [5] lub pluskwy. [6]
Ta infekcja tez może być przekazywana przez ugryzienie zakażonych zwierząt [7], zadrapania [8] lub ewentualnie poprzez transfuzję krwi [9] lub narządu. [10] Istnieje około trzydziestu gatunków Bartonella z tego 17 może zarażać ludzi [11]. Te bakterie stwierdzono przy zapaleniu wątroby, węzłów chłonnych, skóry [12], zębów [13], kości, serce, śledziona, oczy, nerki i mózgu [14].
Ta infekcja wykorzystuje układ krwionośny do rozprzestrzeniania się po całym organizmie..
Bartonella stymuluje wytwarzanie czynnika wzrostu śródbłonka naczyniowego (VEGF)
Antybiotyki są bardzo skuteczne w zabijaniu Bartonella w laboratorium, ale nie sa już tak skuteczne u ludzi.
antybiotyki które zabijają Bartonella:
amoksycylina i ceftriakson, aminoglikozydy, doksycyklina, ryfampicyna, erytromycyna, doksycyklina i cyprofloksacynę [18].
nawroty choroby po używaniu tych antybiotykow :
ryfampicyna, cyprofloksacyna, gentamycyna, współ-trimoksazolem i azytromycyny [19].
Jedną z przyczyn niepowodzenia leczenia to to ze są szczepy Bartonella odporne na :
antybiotyki : chinolony [20], ryfampicyna [21], makrolidy [22], fluorochinolony [23], a gentamycyna [24].
Inną przyczyną niepowodzenia leczenia antybiotykami to to ze bakterie Bartonella tworzą biofilm ( otaczają się żelem, który powoduje iż bakterie staja się niewidoczne dla układu odpornościowego i antybiotyków
W jednym z badań, B. QUINTANA odkryto w egzopolisacharydu (EPS) - w kale wszy [25].
Uważa się, że biofilm powoduje WZROST lekooporności nawet do tysiąca razy. [26]
Ta infekcja może produkować szeroką gamę objawów fizycznych i emocjonalnych.Bartonella może powodować wiele objawów psychicznych. Takich jak :
złość , wściekłość i zaburzenia obsesyjno-kompulsywne (OCD)
Zakażenie Bartonella może powodować objawy niedokrwistości [27],
częste bóle głowy, halucynacje wzrokowe i słuchowe, lęk, utrata wzroku, paraliż, porażenie nerwu twarzowego, chroniczną bezsenność, drgawki, zawroty głowy, zaburzenia funkcji poznawczych i utrata pamięci. [28]
Bartonella naśladuje objawy stwardnienia rozsianego (MS) [29], udar [30], zapalenienaczyń [31], nowotwory piersi, trzustki, dróg żółciowych i rak gardła [32] choroby reumatyczne [33].
Gniew, wściekłość i obsesyjno-kompulsywne zachowania przy Bartonella u pacjenta [34].
[1]“Transmission | Bartonella | CDC.” Accessed July 22, 2016.
http://www.cdc.gov/bartonella/transmission/.
[2]Chomel, B. B., and R. W. Kasten. “Bartonellosis, an Increasingly Recognized Zoonosis.” Journal of Applied Microbiology 109, no. 3 (September 2010): 743–50. doi:10.1111/j.1365-2672.2010.04679.x. http://www.ncbi.nlm.nih.gov/pubmed/20148999
[3]Bradley, Julie M., Patricia E. Mascarelli, Chelsea L. Trull, Ricardo G. Maggi, and Edward B. Breitschwerdt. “Bartonella Henselae Infections in an Owner and Two Papillon Dogs Exposed to Tropical Rat Mites (Ornithonyssus Bacoti).” Vector Borne and Zoonotic Diseases (Larchmont, N.Y.) 14, no. 10 (October 2014): 703–9. doi:10.1089/vbz.2013.1492. http://www.ncbi.nlm.nih.gov/pubmed/25325313
[4]Billeter, S. A., M. G. Levy, B. B. Chomel, and E. B. Breitschwerdt. “Vector Transmission of Bartonella Species with Emphasis on the Potential for Tick Transmission.” Medical and Veterinary Entomology 22, no. 1 (March 2008): 1–15. doi:10.1111/j.1365-2915.2008.00713.x. http://www.ncbi.nlm.nih.gov/pubmed/18380649
[5]Mascarelli, Patricia E., Ricardo G. Maggi, Sarah Hopkins, B. Robert Mozayeni, Chelsea L. Trull, Julie M. Bradley, Barbara C. Hegarty, and Edward B. Breitschwerdt. “Bartonella Henselae Infection in a Family Experiencing Neurological and Neurocognitive Abnormalities after Woodlouse Hunter Spider Bites.” Parasites & Vectors 6 (2013): 98. doi:10.1186/1756-3305-6-98. http://www.ncbi.nlm.nih.gov/pubmed/23587343
[6]Leulmi, Hamza, Idir Bitam, Jean Michel Berenger, Hubert Lepidi, Jean Marc Rolain, Lionel Almeras, Didier Raoult, and Philippe Parola. “Competence of Cimex Lectularius Bed Bugs for the Transmission of Bartonella Quintana, the Agent of Trench Fever.” PLoS Neglected Tropical Diseases 9, no. 5 (May 2015): e0003789. doi:10.1371/journal.pntd.0003789. http://www.ncbi.nlm.nih.gov/pubmed/26000974
[7]Mosbacher, Mark, Sean P. Elliott, Ziad Shehab, Jacob L. Pinnas, John H. Klotz, and Stephen A. Klotz. “Cat Scratch Disease and Arthropod Vectors: More to It than a Scratch?” Journal of the American Board of Family Medicine: JABFM 23, no. 5 (October 2010): 685–86. doi:10.3122/jabfm.2010.05.100025. http://www.ncbi.nlm.nih.gov/pubmed/20823366
[8]Pennisi, Maria Grazia, Fulvio Marsilio, Katrin Hartmann, Albert Lloret, Diane Addie, Sándor Belák, Corine Boucraut-Baralon, et al. “Bartonella Species Infection in Cats: ABCD Guidelines on Prevention and Management.” Journal of Feline Medicine and Surgery 15, no. 7 (July 2013): 563–69. doi:10.1177/1098612X13489214. http://www.ncbi.nlm.nih.gov/pubmed/23813816
[9]Diniz, Pedro Paulo Vissotto de Paiva, Paulo Eduardo Neves Ferreira Velho, Luiza Helena Urso Pitassi, Marina Rovani Drummond, Bruno Grosselli Lania, Maria Lourdes Barjas-Castro, Stanley Sowy, Edward B. Breitschwerdt, and Diana Gerardi Scorpio. “Risk Factors for Bartonella Species Infection in Blood Donors from Southeast Brazil.” PLoS Neglected Tropical Diseases 10, no. 3 (March 2016): e0004509. doi:10.1371/journal.pntd.0004509. http://www.ncbi.nlm.nih.gov/pubmed/26999057
[10]Scolfaro, C., F. Mignone, F. Gennari, A. Alfarano, A. Veltri, R. Romagnoli, and M. Salizzoni. “Possible Donor-Recipient Bartonellosis Transmission in a Pediatric Liver Transplant.” Transplant Infectious Disease: An Official Journal of the Transplantation Society 10, no. 6 (December 2008): 431–33. doi:10.1111/j.1399-3062.2008.00326.x. http://www.ncbi.nlm.nih.gov/pubmed/18651873
[11]Buhner, Stephen Harrod. Healing Lyme Disease Coinfections: Complementary and Holistic Treatments for Bartonella and Mycoplasma. Inner Traditions / Bear & Co, 2013.
[12]Bonatti, Hugo, Julio Mendez, Ivan Guerrero, Murli Krishna, Jaime Ananda-Michel, Joseph Yao, Jeffery L. Steers, Walter Hellinger, Rolland C. Dickson, and Salvador Alvarez. “Disseminated Bartonella Infection Following Liver Transplantation.” Transplant International: Official Journal of the European Society for Organ Transplantation 19, no. 8 (August 2006): 683–87. doi:10.1111/j.1432-2277.2006.00336.x.
http://www.ncbi.nlm.nih.gov/pubmed/16827686
[13]Drancourt, Michel, Lam Tran-Hung, Jean Courtin, Henry de Lumley, and Didier Raoult. “Bartonella Quintana in a 4000-Year-Old Human Tooth.” The Journal of Infectious Diseases 191, no. 4 (February 15, 2005): 607–11. doi:10.1086/427041. http://www.ncbi.nlm.nih.gov/pubmed/15655785
[14]Poudel, Atul, Judy Lew, William Slayton, and Vikas R. Dharnidharka. “Bartonella Henselae Infection Inducing Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Recipient.” Pediatric Transplantation 18, no. 3 (May 2014): E83-87. http://www.ncbi.nlm.nih.gov/pubmed/24829973
[15]“Vascular Endothelial Growth Factor.” Wikipedia, the Free Encyclopedia, July 13, 2016. https://en.wikipedia.org/w/index.php?title=Vascular_endothelial_growth_factor&oldid=729597948.
[16]Berrich, Moez, Claudine Kieda, Catherine Grillon, Martine Monteil, Nathalie Lamerant, Julie Gavard, Henri Jean Boulouis, and Nadia Haddad. “Differential Effects of Bartonella Henselae on Human and Feline Macro- and Micro-Vascular Endothelial Cells.” PLOS ONE 6, no. 5 (May 27, 2011): e20204. doi:10.1371/journal.pone.0020204. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020204
[17]Harms, Alexander, and Christoph Dehio. “Intruders below the Radar: Molecular Pathogenesis of Bartonella Spp.” Clinical Microbiology Reviews 25, no. 1 (January 2012): 42–78. doi:10.1128/CMR.05009-11. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255967/
[18]Rolain, Jean-Marc, Max Maurin, and Didier Raoult. “Bactericidal Effect of Antibiotics on Bartonella and Brucella Spp.: Clinical Implications.” Journal of Antimicrobial Chemotherapy 46, no. 5 (November 1, 2000): 811–14. doi:10.1093/jac/46.5.811. http://jac.oxfordjournals.org/content/46/5/811.full
[19]Rolain, J. M., P. Brouqui, J. E. Koehler, C. Maguina, M. J. Dolan, and D. Raoult. “Recommendations for Treatment of Human Infections Caused by Bartonella Species.” Antimicrobial Agents and Chemotherapy 48, no. 6 (June 2004): 1921–33. doi:10.1128/AAC.48.6.1921-1933.2004. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC415619/
[20]del Valle, Luis J., Lidia Flores, Martha Vargas, Ruth García-de-la-Guarda, Ruth L. Quispe, Zoila B. Ibañez, Débora Alvarado, Pablo Ramírez, and Joaquim Ruiz. “Bartonella Bacilliformis, Endemic Pathogen of the Andean Region, Is Intrinsically Resistant to Quinolones.” International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases 14, no. 6 (June 2010): e506-510. doi:10.1016/j.ijid.2009.07.025. http://www.ncbi.nlm.nih.gov/pubmed/19969497
[21]“Molecular Characterisation of Resistance to Rifampin in Bartonella Quintana – Biswas – 2008 – Clinical Microbiology and Infection – Wiley Online Library.” Accessed July 26, 2016. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02179.x/full. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02179.x/full
[22]Biswas, Silpak, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Macrolides in Bartonella Henselae.” Antimicrobial Agents and Chemotherapy 50, no. 9 (September 2006): 3192–93. doi:10.1128/AAC.00263-06. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563522/
[23]Angelakis, Emmanouil, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Fluoroquinolones in Bartonella Henselae and Bartonella Quintana.” Journal of Antimicrobial Chemotherapy, April 15, 2009, dkp133. doi:10.1093/jac/dkp133. http://jac.oxfordjournals.org/content/early/2009/04/15/jac.dkp133.full
[24]Biswas, S., D. Raoult, and J.-M. Rolain. “Molecular Mechanism of Gentamicin Resistance in Bartonella Henselae.” Clinical Microbiology and Infection 15 (December 1, 2009): 98–99. doi:10.1111/j.1469-0691.2008.02178.x. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02178.x/pdf
[25]Chomel, Bruno B., Henri-Jean Boulouis, Edward B. Breitschwerdt, Rickie W. Kasten, Muriel Vayssier-Taussat, Richard J. Birtles, Jane E. Koehler, and Christoph Dehio. “Ecological Fitness and Strategies of Adaptation of Bartonella Species to Their Hosts and Vectors.” Veterinary Research 40, no. 2 (2009). doi:10.1051/vetres/2009011. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695021/
[26]Chopra, Lipsy, Gurdeep Singh, Kautilya Kumar Jena, and Debendra K. Sahoo. “Sonorensin: A New Bacteriocin with Potential of an Anti-Biofilm Agent and a Food Biopreservative.” Scientific Reports 5 (2015): 13412. doi:10.1038/srep13412. http://www.ncbi.nlm.nih.gov/pubmed/26292786
[27]Van Audenhove, A., G. Verhoef, W. E. Peetermans, M. Boogaerts, and P. Vandenberghe. “Autoimmune Haemolytic Anaemia Triggered by Bartonella Henselae Infection: A Case Report.” British Journal of Haematology 115, no. 4 (December 2001): 924–25. http://www.ncbi.nlm.nih.gov/pubmed/11843827
[28]Balakrishnan, Nandhakumar, Marna Ericson, Ricardo Maggi, and Edward B. Breitschwerdt. “Vasculitis, Cerebral Infarction and Persistent Bartonella Henselae Infection in a Child.” Parasites & Vectors 9, no. 1 (2016): 254. doi:10.1186/s13071-016-1547-9. http://www.ncbi.nlm.nih.gov/pubmed/27161220
[29]Brinar, Vesna V., and Mario Habek. “Rare Infections Mimicking MS.” Clinical Neurology and Neurosurgery 112, no. 7 (September 2010): 625–28. doi:10.1016/j.clineuro.2010.04.011. http://www.ncbi.nlm.nih.gov/pubmed/20439131
[30]Marienfeld, Carla B., Daniel B. Dicapua, Gordon K. Sze, and Jonathan M. Goldstein. “Expressive Aphasia as a Presentation of Encephalitis with Bartonella Henselae Infection in an Immunocompetent Adult.” The Yale Journal of Biology and Medicine 83, no. 2 (June 2010): 67–71. http://www.ncbi.nlm.nih.gov/pubmed/20589186
[31]Teoh, Laurence S G, Hamish H Hart, May Ching Soh, Jonathan P Christiansen, Hasan Bhally, Martin S Philips, and Dominic S Rai-Chaudhuri. “Bartonella Henselae Aortic Valve Endocarditis Mimicking Systemic Vasculitis.” BMJ Case Reports 2010 (October 21, 2010). doi:10.1136/bcr.04.2010.2945. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030181/
[32]Florin, Todd A., Theoklis E. Zaoutis, and Lisa B. Zaoutis. “Beyond Cat Scratch Disease: Widening Spectrum of Bartonella Henselae Infection.” Pediatrics 121, no. 5 (May 2008): e1413-1425. doi:10.1542/peds.2007-1897. http://www.ncbi.nlm.nih.gov/pubmed/18443019
[33]Maggi, Ricardo G., B. Robert Mozayeni, Elizabeth L. Pultorak, Barbara C. Hegarty, Julie M. Bradley, Maria Correa, and Edward B. Breitschwerdt. “Bartonella Spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region.” Emerging Infectious Diseases 18, no. 5 (May 2012). doi:10.3201/eid1805.111366. http://wwwnc.cdc.gov/eid/article/18/5/11-1366_article
[34]Corson, A. The Diagnosis and Treatment of Tick-Borne Diseases. Lyme Disease in the Family Conference. Salisbury, MD July 9th, 2011.
[35]Marconi, Daniela, Lucilla Limpido, Iliana Bersani, Annalisa Giordano, and Giuseppe Bersani. “[PANDAS: a possible model for adult OCD pathogenesis].” Rivista Di Psichiatria 44, no. 5 (October 2009): 285–98. http://www.ncbi.nlm.nih.gov/pubmed/20066816
[36]Orefici, Graziella, Francesco Cardona, Carol J. Cox, and Madeleine W. Cunningham. “Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS).” In Streptococcus Pyogenes: Basic Biology to Clinical Manifestations, edited by Joseph J. Ferretti, Dennis L. Stevens, and Vincent A. Fischetti. Oklahoma City (OK): University of Oklahoma Health Sciences Center, 2016. http://www.ncbi.nlm.nih.gov/books/NBK333433/. http://www.ncbi.nlm.nih.gov/pubmed/26866234
[37]Florin, Todd A., Theoklis E. Zaoutis, and Lisa B. Zaoutis. “Beyond Cat Scratch Disease: Widening Spectrum of Bartonella Henselae Infection.” P. 1417.
[38]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. http://www.itmonline.org/5organs/liver.htm.
[39]“Obsessive-Compulsive Disorder – Encyclopedia of Alternative Medicine – altMD.com Article.” Accessed July 28, 2016. http://www.altmd.com/Articles/Obsessive-Compulsive-Disorder–Encyclopedia-of-Alt.
[40]Administrator. “An Ancient Solution for Modern Diseases: ‘Gu Syndrome’ and Chronic Inflammatory Diseases with Autoimmune Complications (An Interview with Heiner Fruehauf).” ClassicalChineseMedicine.org, December 15, 2012. https://classicalchinesemedicine.org/gpa/ancient-solution-modern-diseases-gu-syndrome-chronic-inflammatory-diseases-autoimmune-complications/.
[41]Santos, Adriana O., Lígia C. Gomes da Silva, Luís M. Bimbo, Maria C. Pedroso de Lima, Sérgio Simões, and João N. Moreira. “Design of Peptide-Targeted Liposomes Containing Nucleic Acids.” Biochimica Et Biophysica Acta 1798, no. 3 (March 2010): 433–41. doi:10.1016/j.bbamem.2009.12.001. http://www.ncbi.nlm.nih.gov/pubmed/20004174
[42]Elmowafy, Mohammed, Tapani Viitala, Hany M. Ibrahim, Sherif K. Abu-Elyazid, Ahmed Samy, Alaa Kassem, and Marjo Yliperttula. “Silymarin Loaded Liposomes for Hepatic Targeting: In Vitro Evaluation and HepG2 Drug Uptake.” European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 50, no. 2 (October 9, 2013): 161–71. doi:10.1016/j.ejps.2013.06.012. http://www.ncbi.nlm.nih.gov/pubmed/23851081
[43]Mora, Margarita, Maria-Luisa Sagristá, Domenico Trombetta, Francesco P. Bonina, Anna De Pasquale, and Antonella Saija. “Design and Characterization of Liposomes Containing Long-Chain N-acylPEs for Brain Delivery: Penetration of Liposomes Incorporating GM1 into the Rat Brain.” Pharmaceutical Research 19, no. 10 (October 2002): 1430–38. http://www.ncbi.nlm.nih.gov/pubmed/12425459
[44]Leite, Elaine A., Cristina M. Souza, Alvaro D. Carvalho-Júnior, Luiz G. V. Coelho, Angela M. Q. Lana, Geovanni D. Cassali, and Mônica C. Oliveira. “Encapsulation of Cisplatin in Long-Circulating and pH-Sensitive Liposomes Improves Its Antitumor Effect and Reduces Acute Toxicity.” International Journal of Nanomedicine 7 (2012): 5259–69. doi:10.2147/IJN.S34652. http://www.ncbi.nlm.nih.gov/pubmed/23091378
[45]Wicki, Andreas, Christoph Rochlitz, Annette Orleth, Reto Ritschard, Imke Albrecht, Richard Herrmann, Gerhard Christofori, and Christoph Mamot. “Targeting Tumor-Associated Endothelial Cells: Anti-VEGFR2 Immunoliposomes Mediate Tumor Vessel Disruption and Inhibit Tumor Growth.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 18, no. 2 (January 15, 2012): 454–64. doi:10.1158/1078-0432.CCR-11-1102. http://www.ncbi.nlm.nih.gov/pubmed/22065082
[46]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 918-924.
[47]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. http://www.itmonline.org/5organs/liver.htm.
[48]Lee, Wei-Hwa, Jong-Shiaw Jin, Wen-Chiuan Tsai, Yu-Ting Chen, Wen-Liang Chang, Chen-Wen Yao, Lia-Fa Sheu, and Ann Chen. “Biological Inhibitory Effects of the Chinese Herb Danggui on Brain Astrocytoma.” Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology 73, no. 3 (2006): 141–48. doi:10.1159/000095560. https://tmu.pure.elsevier.com/en/publications/biological-inhibitory-effects-of-the-chinese-herb-danggui-on-brai
[49]Deng, Min, Huimin Sun, Jun Shen, Yuanteng Fan, Lei Zhang, and Junjian Zhang. “Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats.” Current Neurovascular Research 12, no. 3 (July 7, 2015): 232–39. doi:10.2174/1567202612666150603125710. http://m.eurekaselect.com/131933/article
[50]Wang, Haichao, Wei Li, Jianhua Li, Beatriz Rendon-Mitchell, Mahendar Ochani, Mala Ashok, Lihong Yang, et al. “The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica Sinensis, Protects Mice against Lethal Endotoxemia and Sepsis.” The Journal of Nutrition 136, no. 2 (February 2006): 360–65. http://www.ncbi.nlm.nih.gov/pubmed/16424112
[51]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. p. 921.
[52]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 930-934.
[53]Zhu, L., W. Wei, Y.-Q. Zheng, and X.-Y. Jia. “Effects and Mechanisms of Total Glucosides of Paeony on Joint Damage in Rat Collagen-Induced Arthritis.” Inflammation Research: Official Journal of the European Histamine Research Society … [et Al.] 54, no. 5 (May 2005): 211–20. doi:10.1007/s00011-005-1345-x. http://www.ncbi.nlm.nih.gov/pubmed/15953993
[54]Kim, In Deok, and Bae Jin Ha. “The Effects of Paeoniflorin on LPS-Induced Liver Inflammatory Reactions.” Archives of Pharmacal Research 33, no. 6 (June 2010): 959–66. doi:10.1007/s12272-010-0620-8. http://www.ncbi.nlm.nih.gov/pubmed/20607502
[55]Liu, Ling, Xiang-jun Qiu, Su-na He, Hui Yang, Deng Wang, and Xue-mei Yang. “[Effect of paeoniflorin on oxidative stress and energy metabolism in mice with lipopolysaccharide (LPS)-induced brain injury].” Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica 40, no. 14 (July 2015): 2871–75. http://www.ncbi.nlm.nih.gov/pubmed/26666042
[56]Wang, Qiang-Song, Teng Gao, Yuan-Lu Cui, Li-Na Gao, and Heng-Li Jiang. “Comparative Studies of Paeoniflorin and Albiflorin from Paeonia Lactiflora on Anti-Inflammatory Activities.” Pharmaceutical Biology 52, no. 9 (September 2014): 1189–95. doi:10.3109/13880209.2014.880490. http://www.ncbi.nlm.nih.gov/pubmed/24646307
[57]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. p. 932.
[58]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. http://www.itmonline.org/5organs/liver.htm.
[59]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 84-87.
[60]“Towards a Spirit at Peace – Chapter 8: Traditional Herb Formulas.” Accessed July 28, 2016. http://www.itmonline.org/shen/chap8.htm.
[61]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. p. 85.
[62]Wu, Jian, Yun-Yi Zhang, Li Guo, Hong Li, and Dao-Feng Chen. “Bupleurum Polysaccharides Attenuates Lipopolysaccharide-Induced Inflammation via Modulating Toll-like Receptor 4 Signaling.” PloS One 8, no. 10 (2013): e78051. doi:10.1371/journal.pone.0078051. http://www.ncbi.nlm.nih.gov/pubmed/24167596
[63]Wang, Xia, Qing Feng, Yong Xiao, and Ping Li. “Radix Bupleuri Ameliorates Depression by Increasing Nerve Growth Factor and Brain-Derived Neurotrophic Factor.” International Journal of Clinical and Experimental Medicine 8, no. 6 (2015): 9205–17. http://www.ncbi.nlm.nih.gov/pubmed/26309578
[64]Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. http://www.ncbi.nlm.nih.gov/pubmed/22562737
[65]Beau. “Psychospiritual Aspects of Herbal Medicine.” Accessed July 28, 2016. https://www.planetherbs.com/theory/psychospiritual-aspects-of-herbal-medicine.html.
[66]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/
[67]Beau. “Ashwagandha: Wonder Herb of India.” Accessed July 28, 2016. https://www.planetherbs.com/specific-herbs/ashwagandha-wonder-herb-of-india.html.
[68]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/
[69]Kaurav, Bhanu P. S., Manish M. Wanjari, Amol Chandekar, Nagendra Singh Chauhan, and Neeraj Upmanyu. “Influence of Withania Somnifera on Obsessive Compulsive Disorder in Mice.” Asian Pacific Journal of Tropical Medicine 5, no. 5 (May 2012): 380–84. doi:10.1016/S1995-7645(12)60063-7. http://www.ncbi.nlm.nih.gov/pubmed/22546655
[70]Sultana, N. “Hepatoprotective Role of Ashwagandha (Withania Somnifera) Root Extract against Gentamicin Induced Liver Damage in Rats.” Proceedings of The Physiological Society Proc 37th IUPS (2013). http://www.physoc.org/proceedings/abstract/Proc%2037th%20IUPSPCB197.
[71]Mwitari, Peter G., Peter A. Ayeka, Joyce Ondicho, Esther N. Matu, and Christine C. Bii. “Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania Somnifera, Warbugia Ugandensis, Prunus Africana and Plectrunthus Barbatus.” PLoS ONE 8, no. 6 (June 13, 2013). doi:10.1371/journal.pone.0065619. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681961/
[72]Bisht, Punum, and Vinita Rawat. “Antibacterial Activity of Withania Somnifera against Gram-Positive Isolates from Pus Samples.” Ayu 35, no. 3 (September 2014): 330–32. doi:10.4103/0974-8520.153757. http://www.ncbi.nlm.nih.gov/pubmed/25972723
[73]Alam, Nadia, Monzur Hossain, Md Abdul Mottalib, Siti Amrah Sulaiman, Siew Hua Gan, and Md Ibrahim Khalil. “Methanolic Extracts of Withania Somnifera Leaves, Fruits and Roots Possess Antioxidant Properties and Antibacterial Activities.” BMC Complementary and Alternative Medicine 12 (October 7, 2012): 175. doi:10.1186/1472-6882-12-175. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527235/
[74]Sharma, Arun, Ashutosh D. Deo, S. Tandel Riteshkumar, Thongam Ibemcha Chanu, and Arabinda Das. “Effect of Withania Somnifera (L. Dunal) Root as a Feed Additive on Immunological Parameters and Disease Resistance to Aeromonas Hydrophila in Labeo Rohita (Hamilton) Fingerlings.” Fish & Shellfish Immunology 29, no. 3 (September 2010): 508–12. doi:10.1016/j.fsi.2010.05.005. http://www.ncbi.nlm.nih.gov/pubmed/20580830
[75]Dikasso, Dawit, Eyassu Makonnen, Asfaw Debella, Dawit Abebe, Kelbessa Urga, Wallelign Makonnen, Daniel Melaku, Moges Kassa, and Mulugeta Guta. “Anti-Malarial Activity of Withania Somnifera L. Dunal Extracts in Mice.” Ethiopian Medical Journal 44, no. 3 (July 2006): 279–85. http://www.ncbi.nlm.nih.gov/pubmed/17447395
[76]Pandit, S., J. N. Cai, K. Y. Song, and J. G. Jeon. “Identification of Anti-Biofilm Components in Withania Somnifera and Their Effect on Virulence of Streptococcus Mutans Biofilms.” Journal of Applied Microbiology 119, no. 2 (August 2015): 571–81. doi:10.1111/jam.12851. http://www.ncbi.nlm.nih.gov/pubmed/25976122
[77]Grover, Abhinav, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey, and Durai Sundar. “Blocking Protein Kinase C Signaling Pathway: Mechanistic Insights into the Anti-Leishmanial Activity of Prospective Herbal Drugs from Withania Somnifera.” BMC Genomics 13 Suppl 7 (2012): S20. doi:10.1186/1471-2164-13-S7-S20. http://www.ncbi.nlm.nih.gov/pubmed/23281834
[78]Kim, Jae-Eun, Jun-Young Lee, Min-Jung Kang, Yu-Jin Jeong, Jin-A. Choi, Sang-Muk Oh, Kyung-Bok Lee, and Jong-Hwan Park. “Withaferin A Inhibits Helicobacter Pylori-Induced Production of IL-1β in Dendritic Cells by Regulating NF-κB and NLRP3 Inflammasome Activation.” Immune Network 15, no. 6 (December 2015): 269–77. doi:10.4110/in.2015.15.6.269. http://www.ncbi.nlm.nih.gov/pubmed/26770181
[79]Lee, Dae Hyung, In-Hye Lim, Eon-Gi Sung, Joo-Young Kim, In-Hwan Song, Yoon Ki Park, and Tae-Jin Lee. “Withaferin A Inhibits Matrix Metalloproteinase-9 Activity by Suppressing the Akt Signaling Pathway.” Oncology Reports 30, no. 2 (August 2013): 933–38. doi:10.3892/or.2013.2487. http://www.ncbi.nlm.nih.gov/pubmed/23708780
[80]Kataria, Hardeep, Sushil Kumar, Harshita Chaudhary, and Gurcharan Kaur. “Withania Somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.” Molecular Neurobiology 53, no. 6 (August 2016): 4143–58. doi:10.1007/s12035-015-9320-1. http://www.ncbi.nlm.nih.gov/pubmed/26208698 http://goodbyelyme.com/stop_bartonella_rage_ocd
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..... ,,And while flea-infested cats are known for transmitting Bartonella henselae, here’s a case Breitschwerdt published involving an 11-year old Ottawa girl who presumably got a Bartonella henselae infection after nursing an oozing abscess in an ill dog the family adopted from a shelter. The dog had been certified healthy. The child suddenly developed headaches, difficulty walking and weakness on her left side. According to the case study, “A few weeks later, the girl developed flu-like symptoms followed by progressive neurological abnormalities.” Three years after the exposure, “the patient experienced frequent headaches, chest pain, visual and auditory hallucinations, anxiety, ocular floaters, severe depression, and fatigue. Additional episodes of partial paralysis occurred.” Eleven years later, after seeing a physician in Vancouver, Canada (2,700 miles west of Ottawa) the child finally received a diagnosis and treatment.
My daughter’s Bartonella infection came from two simultaneous tick bites, and like many people infected with Bartonella, she developed a distinctive red-streaked rash. She suffered from headaches, dizziness and neurological symptoms, consistent with neurobartonellosis. She spent more time in bed than out. Four years after the initial bites (and numerous doctor visits) a psychiatrist diagnosed Bartonella when he saw her rashes,,.....................
http://www.phillyvoice.com/bartonella-infection-steals-life-long-it-kills/
Bartonella jest zakażeniem bakteryjnym Gram-ujemne bakterie które mogą być przenoszone przez owady, pchły, wszy, moskity [1], odchody pcheł, [2] roztocza [3], przez kleszcze [4], pająki [5] lub pluskwy. [6]
Ta infekcja tez może być przekazywana przez ugryzienie zakażonych zwierząt [7], zadrapania [8] lub ewentualnie poprzez transfuzję krwi [9] lub narządu. [10] Istnieje około trzydziestu gatunków Bartonella z tego 17 może zarażać ludzi [11]. Te bakterie stwierdzono przy zapaleniu wątroby, węzłów chłonnych, skóry [12], zębów [13], kości, serce, śledziona, oczy, nerki i mózgu [14].
Ta infekcja wykorzystuje układ krwionośny do rozprzestrzeniania się po całym organizmie..
Bartonella stymuluje wytwarzanie czynnika wzrostu śródbłonka naczyniowego (VEGF)
Antybiotyki są bardzo skuteczne w zabijaniu Bartonella w laboratorium, ale nie sa już tak skuteczne u ludzi.
antybiotyki które zabijają Bartonella:
amoksycylina i ceftriakson, aminoglikozydy, doksycyklina, ryfampicyna, erytromycyna, doksycyklina i cyprofloksacynę [18].
nawroty choroby po używaniu tych antybiotykow :
ryfampicyna, cyprofloksacyna, gentamycyna, współ-trimoksazolem i azytromycyny [19].
Jedną z przyczyn niepowodzenia leczenia to to ze są szczepy Bartonella odporne na :
antybiotyki : chinolony [20], ryfampicyna [21], makrolidy [22], fluorochinolony [23], a gentamycyna [24].
Inną przyczyną niepowodzenia leczenia antybiotykami to to ze bakterie Bartonella tworzą biofilm ( otaczają się żelem, który powoduje iż bakterie staja się niewidoczne dla układu odpornościowego i antybiotyków
W jednym z badań, B. QUINTANA odkryto w egzopolisacharydu (EPS) - w kale wszy [25].
Uważa się, że biofilm powoduje WZROST lekooporności nawet do tysiąca razy. [26]
Ta infekcja może produkować szeroką gamę objawów fizycznych i emocjonalnych.Bartonella może powodować wiele objawów psychicznych. Takich jak :
złość , wściekłość i zaburzenia obsesyjno-kompulsywne (OCD)
Zakażenie Bartonella może powodować objawy niedokrwistości [27],
częste bóle głowy, halucynacje wzrokowe i słuchowe, lęk, utrata wzroku, paraliż, porażenie nerwu twarzowego, chroniczną bezsenność, drgawki, zawroty głowy, zaburzenia funkcji poznawczych i utrata pamięci. [28]
Bartonella naśladuje objawy stwardnienia rozsianego (MS) [29], udar [30], zapalenienaczyń [31], nowotwory piersi, trzustki, dróg żółciowych i rak gardła [32] choroby reumatyczne [33].
Gniew, wściekłość i obsesyjno-kompulsywne zachowania przy Bartonella u pacjenta [34].
[1]“Transmission | Bartonella | CDC.” Accessed July 22, 2016.
http://www.cdc.gov/bartonella/transmission/.
[2]Chomel, B. B., and R. W. Kasten. “Bartonellosis, an Increasingly Recognized Zoonosis.” Journal of Applied Microbiology 109, no. 3 (September 2010): 743–50. doi:10.1111/j.1365-2672.2010.04679.x. http://www.ncbi.nlm.nih.gov/pubmed/20148999
[3]Bradley, Julie M., Patricia E. Mascarelli, Chelsea L. Trull, Ricardo G. Maggi, and Edward B. Breitschwerdt. “Bartonella Henselae Infections in an Owner and Two Papillon Dogs Exposed to Tropical Rat Mites (Ornithonyssus Bacoti).” Vector Borne and Zoonotic Diseases (Larchmont, N.Y.) 14, no. 10 (October 2014): 703–9. doi:10.1089/vbz.2013.1492. http://www.ncbi.nlm.nih.gov/pubmed/25325313
[4]Billeter, S. A., M. G. Levy, B. B. Chomel, and E. B. Breitschwerdt. “Vector Transmission of Bartonella Species with Emphasis on the Potential for Tick Transmission.” Medical and Veterinary Entomology 22, no. 1 (March 2008): 1–15. doi:10.1111/j.1365-2915.2008.00713.x. http://www.ncbi.nlm.nih.gov/pubmed/18380649
[5]Mascarelli, Patricia E., Ricardo G. Maggi, Sarah Hopkins, B. Robert Mozayeni, Chelsea L. Trull, Julie M. Bradley, Barbara C. Hegarty, and Edward B. Breitschwerdt. “Bartonella Henselae Infection in a Family Experiencing Neurological and Neurocognitive Abnormalities after Woodlouse Hunter Spider Bites.” Parasites & Vectors 6 (2013): 98. doi:10.1186/1756-3305-6-98. http://www.ncbi.nlm.nih.gov/pubmed/23587343
[6]Leulmi, Hamza, Idir Bitam, Jean Michel Berenger, Hubert Lepidi, Jean Marc Rolain, Lionel Almeras, Didier Raoult, and Philippe Parola. “Competence of Cimex Lectularius Bed Bugs for the Transmission of Bartonella Quintana, the Agent of Trench Fever.” PLoS Neglected Tropical Diseases 9, no. 5 (May 2015): e0003789. doi:10.1371/journal.pntd.0003789. http://www.ncbi.nlm.nih.gov/pubmed/26000974
[7]Mosbacher, Mark, Sean P. Elliott, Ziad Shehab, Jacob L. Pinnas, John H. Klotz, and Stephen A. Klotz. “Cat Scratch Disease and Arthropod Vectors: More to It than a Scratch?” Journal of the American Board of Family Medicine: JABFM 23, no. 5 (October 2010): 685–86. doi:10.3122/jabfm.2010.05.100025. http://www.ncbi.nlm.nih.gov/pubmed/20823366
[8]Pennisi, Maria Grazia, Fulvio Marsilio, Katrin Hartmann, Albert Lloret, Diane Addie, Sándor Belák, Corine Boucraut-Baralon, et al. “Bartonella Species Infection in Cats: ABCD Guidelines on Prevention and Management.” Journal of Feline Medicine and Surgery 15, no. 7 (July 2013): 563–69. doi:10.1177/1098612X13489214. http://www.ncbi.nlm.nih.gov/pubmed/23813816
[9]Diniz, Pedro Paulo Vissotto de Paiva, Paulo Eduardo Neves Ferreira Velho, Luiza Helena Urso Pitassi, Marina Rovani Drummond, Bruno Grosselli Lania, Maria Lourdes Barjas-Castro, Stanley Sowy, Edward B. Breitschwerdt, and Diana Gerardi Scorpio. “Risk Factors for Bartonella Species Infection in Blood Donors from Southeast Brazil.” PLoS Neglected Tropical Diseases 10, no. 3 (March 2016): e0004509. doi:10.1371/journal.pntd.0004509. http://www.ncbi.nlm.nih.gov/pubmed/26999057
[10]Scolfaro, C., F. Mignone, F. Gennari, A. Alfarano, A. Veltri, R. Romagnoli, and M. Salizzoni. “Possible Donor-Recipient Bartonellosis Transmission in a Pediatric Liver Transplant.” Transplant Infectious Disease: An Official Journal of the Transplantation Society 10, no. 6 (December 2008): 431–33. doi:10.1111/j.1399-3062.2008.00326.x. http://www.ncbi.nlm.nih.gov/pubmed/18651873
[11]Buhner, Stephen Harrod. Healing Lyme Disease Coinfections: Complementary and Holistic Treatments for Bartonella and Mycoplasma. Inner Traditions / Bear & Co, 2013.
[12]Bonatti, Hugo, Julio Mendez, Ivan Guerrero, Murli Krishna, Jaime Ananda-Michel, Joseph Yao, Jeffery L. Steers, Walter Hellinger, Rolland C. Dickson, and Salvador Alvarez. “Disseminated Bartonella Infection Following Liver Transplantation.” Transplant International: Official Journal of the European Society for Organ Transplantation 19, no. 8 (August 2006): 683–87. doi:10.1111/j.1432-2277.2006.00336.x.
http://www.ncbi.nlm.nih.gov/pubmed/16827686
[13]Drancourt, Michel, Lam Tran-Hung, Jean Courtin, Henry de Lumley, and Didier Raoult. “Bartonella Quintana in a 4000-Year-Old Human Tooth.” The Journal of Infectious Diseases 191, no. 4 (February 15, 2005): 607–11. doi:10.1086/427041. http://www.ncbi.nlm.nih.gov/pubmed/15655785
[14]Poudel, Atul, Judy Lew, William Slayton, and Vikas R. Dharnidharka. “Bartonella Henselae Infection Inducing Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Recipient.” Pediatric Transplantation 18, no. 3 (May 2014): E83-87. http://www.ncbi.nlm.nih.gov/pubmed/24829973
[15]“Vascular Endothelial Growth Factor.” Wikipedia, the Free Encyclopedia, July 13, 2016. https://en.wikipedia.org/w/index.php?title=Vascular_endothelial_growth_factor&oldid=729597948.
[16]Berrich, Moez, Claudine Kieda, Catherine Grillon, Martine Monteil, Nathalie Lamerant, Julie Gavard, Henri Jean Boulouis, and Nadia Haddad. “Differential Effects of Bartonella Henselae on Human and Feline Macro- and Micro-Vascular Endothelial Cells.” PLOS ONE 6, no. 5 (May 27, 2011): e20204. doi:10.1371/journal.pone.0020204. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020204
[17]Harms, Alexander, and Christoph Dehio. “Intruders below the Radar: Molecular Pathogenesis of Bartonella Spp.” Clinical Microbiology Reviews 25, no. 1 (January 2012): 42–78. doi:10.1128/CMR.05009-11. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255967/
[18]Rolain, Jean-Marc, Max Maurin, and Didier Raoult. “Bactericidal Effect of Antibiotics on Bartonella and Brucella Spp.: Clinical Implications.” Journal of Antimicrobial Chemotherapy 46, no. 5 (November 1, 2000): 811–14. doi:10.1093/jac/46.5.811. http://jac.oxfordjournals.org/content/46/5/811.full
[19]Rolain, J. M., P. Brouqui, J. E. Koehler, C. Maguina, M. J. Dolan, and D. Raoult. “Recommendations for Treatment of Human Infections Caused by Bartonella Species.” Antimicrobial Agents and Chemotherapy 48, no. 6 (June 2004): 1921–33. doi:10.1128/AAC.48.6.1921-1933.2004. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC415619/
[20]del Valle, Luis J., Lidia Flores, Martha Vargas, Ruth García-de-la-Guarda, Ruth L. Quispe, Zoila B. Ibañez, Débora Alvarado, Pablo Ramírez, and Joaquim Ruiz. “Bartonella Bacilliformis, Endemic Pathogen of the Andean Region, Is Intrinsically Resistant to Quinolones.” International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases 14, no. 6 (June 2010): e506-510. doi:10.1016/j.ijid.2009.07.025. http://www.ncbi.nlm.nih.gov/pubmed/19969497
[21]“Molecular Characterisation of Resistance to Rifampin in Bartonella Quintana – Biswas – 2008 – Clinical Microbiology and Infection – Wiley Online Library.” Accessed July 26, 2016. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02179.x/full. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02179.x/full
[22]Biswas, Silpak, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Macrolides in Bartonella Henselae.” Antimicrobial Agents and Chemotherapy 50, no. 9 (September 2006): 3192–93. doi:10.1128/AAC.00263-06. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563522/
[23]Angelakis, Emmanouil, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Fluoroquinolones in Bartonella Henselae and Bartonella Quintana.” Journal of Antimicrobial Chemotherapy, April 15, 2009, dkp133. doi:10.1093/jac/dkp133. http://jac.oxfordjournals.org/content/early/2009/04/15/jac.dkp133.full
[24]Biswas, S., D. Raoult, and J.-M. Rolain. “Molecular Mechanism of Gentamicin Resistance in Bartonella Henselae.” Clinical Microbiology and Infection 15 (December 1, 2009): 98–99. doi:10.1111/j.1469-0691.2008.02178.x. http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02178.x/pdf
[25]Chomel, Bruno B., Henri-Jean Boulouis, Edward B. Breitschwerdt, Rickie W. Kasten, Muriel Vayssier-Taussat, Richard J. Birtles, Jane E. Koehler, and Christoph Dehio. “Ecological Fitness and Strategies of Adaptation of Bartonella Species to Their Hosts and Vectors.” Veterinary Research 40, no. 2 (2009). doi:10.1051/vetres/2009011. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695021/
[26]Chopra, Lipsy, Gurdeep Singh, Kautilya Kumar Jena, and Debendra K. Sahoo. “Sonorensin: A New Bacteriocin with Potential of an Anti-Biofilm Agent and a Food Biopreservative.” Scientific Reports 5 (2015): 13412. doi:10.1038/srep13412. http://www.ncbi.nlm.nih.gov/pubmed/26292786
[27]Van Audenhove, A., G. Verhoef, W. E. Peetermans, M. Boogaerts, and P. Vandenberghe. “Autoimmune Haemolytic Anaemia Triggered by Bartonella Henselae Infection: A Case Report.” British Journal of Haematology 115, no. 4 (December 2001): 924–25. http://www.ncbi.nlm.nih.gov/pubmed/11843827
[28]Balakrishnan, Nandhakumar, Marna Ericson, Ricardo Maggi, and Edward B. Breitschwerdt. “Vasculitis, Cerebral Infarction and Persistent Bartonella Henselae Infection in a Child.” Parasites & Vectors 9, no. 1 (2016): 254. doi:10.1186/s13071-016-1547-9. http://www.ncbi.nlm.nih.gov/pubmed/27161220
[29]Brinar, Vesna V., and Mario Habek. “Rare Infections Mimicking MS.” Clinical Neurology and Neurosurgery 112, no. 7 (September 2010): 625–28. doi:10.1016/j.clineuro.2010.04.011. http://www.ncbi.nlm.nih.gov/pubmed/20439131
[30]Marienfeld, Carla B., Daniel B. Dicapua, Gordon K. Sze, and Jonathan M. Goldstein. “Expressive Aphasia as a Presentation of Encephalitis with Bartonella Henselae Infection in an Immunocompetent Adult.” The Yale Journal of Biology and Medicine 83, no. 2 (June 2010): 67–71. http://www.ncbi.nlm.nih.gov/pubmed/20589186
[31]Teoh, Laurence S G, Hamish H Hart, May Ching Soh, Jonathan P Christiansen, Hasan Bhally, Martin S Philips, and Dominic S Rai-Chaudhuri. “Bartonella Henselae Aortic Valve Endocarditis Mimicking Systemic Vasculitis.” BMJ Case Reports 2010 (October 21, 2010). doi:10.1136/bcr.04.2010.2945. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030181/
[32]Florin, Todd A., Theoklis E. Zaoutis, and Lisa B. Zaoutis. “Beyond Cat Scratch Disease: Widening Spectrum of Bartonella Henselae Infection.” Pediatrics 121, no. 5 (May 2008): e1413-1425. doi:10.1542/peds.2007-1897. http://www.ncbi.nlm.nih.gov/pubmed/18443019
[33]Maggi, Ricardo G., B. Robert Mozayeni, Elizabeth L. Pultorak, Barbara C. Hegarty, Julie M. Bradley, Maria Correa, and Edward B. Breitschwerdt. “Bartonella Spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region.” Emerging Infectious Diseases 18, no. 5 (May 2012). doi:10.3201/eid1805.111366. http://wwwnc.cdc.gov/eid/article/18/5/11-1366_article
[34]Corson, A. The Diagnosis and Treatment of Tick-Borne Diseases. Lyme Disease in the Family Conference. Salisbury, MD July 9th, 2011.
[35]Marconi, Daniela, Lucilla Limpido, Iliana Bersani, Annalisa Giordano, and Giuseppe Bersani. “[PANDAS: a possible model for adult OCD pathogenesis].” Rivista Di Psichiatria 44, no. 5 (October 2009): 285–98. http://www.ncbi.nlm.nih.gov/pubmed/20066816
[36]Orefici, Graziella, Francesco Cardona, Carol J. Cox, and Madeleine W. Cunningham. “Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS).” In Streptococcus Pyogenes: Basic Biology to Clinical Manifestations, edited by Joseph J. Ferretti, Dennis L. Stevens, and Vincent A. Fischetti. Oklahoma City (OK): University of Oklahoma Health Sciences Center, 2016. http://www.ncbi.nlm.nih.gov/books/NBK333433/. http://www.ncbi.nlm.nih.gov/pubmed/26866234
[37]Florin, Todd A., Theoklis E. Zaoutis, and Lisa B. Zaoutis. “Beyond Cat Scratch Disease: Widening Spectrum of Bartonella Henselae Infection.” P. 1417.
[38]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. http://www.itmonline.org/5organs/liver.htm.
[39]“Obsessive-Compulsive Disorder – Encyclopedia of Alternative Medicine – altMD.com Article.” Accessed July 28, 2016. http://www.altmd.com/Articles/Obsessive-Compulsive-Disorder–Encyclopedia-of-Alt.
[40]Administrator. “An Ancient Solution for Modern Diseases: ‘Gu Syndrome’ and Chronic Inflammatory Diseases with Autoimmune Complications (An Interview with Heiner Fruehauf).” ClassicalChineseMedicine.org, December 15, 2012. https://classicalchinesemedicine.org/gpa/ancient-solution-modern-diseases-gu-syndrome-chronic-inflammatory-diseases-autoimmune-complications/.
[41]Santos, Adriana O., Lígia C. Gomes da Silva, Luís M. Bimbo, Maria C. Pedroso de Lima, Sérgio Simões, and João N. Moreira. “Design of Peptide-Targeted Liposomes Containing Nucleic Acids.” Biochimica Et Biophysica Acta 1798, no. 3 (March 2010): 433–41. doi:10.1016/j.bbamem.2009.12.001. http://www.ncbi.nlm.nih.gov/pubmed/20004174
[42]Elmowafy, Mohammed, Tapani Viitala, Hany M. Ibrahim, Sherif K. Abu-Elyazid, Ahmed Samy, Alaa Kassem, and Marjo Yliperttula. “Silymarin Loaded Liposomes for Hepatic Targeting: In Vitro Evaluation and HepG2 Drug Uptake.” European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 50, no. 2 (October 9, 2013): 161–71. doi:10.1016/j.ejps.2013.06.012. http://www.ncbi.nlm.nih.gov/pubmed/23851081
[43]Mora, Margarita, Maria-Luisa Sagristá, Domenico Trombetta, Francesco P. Bonina, Anna De Pasquale, and Antonella Saija. “Design and Characterization of Liposomes Containing Long-Chain N-acylPEs for Brain Delivery: Penetration of Liposomes Incorporating GM1 into the Rat Brain.” Pharmaceutical Research 19, no. 10 (October 2002): 1430–38. http://www.ncbi.nlm.nih.gov/pubmed/12425459
[44]Leite, Elaine A., Cristina M. Souza, Alvaro D. Carvalho-Júnior, Luiz G. V. Coelho, Angela M. Q. Lana, Geovanni D. Cassali, and Mônica C. Oliveira. “Encapsulation of Cisplatin in Long-Circulating and pH-Sensitive Liposomes Improves Its Antitumor Effect and Reduces Acute Toxicity.” International Journal of Nanomedicine 7 (2012): 5259–69. doi:10.2147/IJN.S34652. http://www.ncbi.nlm.nih.gov/pubmed/23091378
[45]Wicki, Andreas, Christoph Rochlitz, Annette Orleth, Reto Ritschard, Imke Albrecht, Richard Herrmann, Gerhard Christofori, and Christoph Mamot. “Targeting Tumor-Associated Endothelial Cells: Anti-VEGFR2 Immunoliposomes Mediate Tumor Vessel Disruption and Inhibit Tumor Growth.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 18, no. 2 (January 15, 2012): 454–64. doi:10.1158/1078-0432.CCR-11-1102. http://www.ncbi.nlm.nih.gov/pubmed/22065082
[46]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 918-924.
[47]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. http://www.itmonline.org/5organs/liver.htm.
[48]Lee, Wei-Hwa, Jong-Shiaw Jin, Wen-Chiuan Tsai, Yu-Ting Chen, Wen-Liang Chang, Chen-Wen Yao, Lia-Fa Sheu, and Ann Chen. “Biological Inhibitory Effects of the Chinese Herb Danggui on Brain Astrocytoma.” Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology 73, no. 3 (2006): 141–48. doi:10.1159/000095560. https://tmu.pure.elsevier.com/en/publications/biological-inhibitory-effects-of-the-chinese-herb-danggui-on-brai
[49]Deng, Min, Huimin Sun, Jun Shen, Yuanteng Fan, Lei Zhang, and Junjian Zhang. “Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats.” Current Neurovascular Research 12, no. 3 (July 7, 2015): 232–39. doi:10.2174/1567202612666150603125710. http://m.eurekaselect.com/131933/article
[50]Wang, Haichao, Wei Li, Jianhua Li, Beatriz Rendon-Mitchell, Mahendar Ochani, Mala Ashok, Lihong Yang, et al. “The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica Sinensis, Protects Mice against Lethal Endotoxemia and Sepsis.” The Journal of Nutrition 136, no. 2 (February 2006): 360–65. http://www.ncbi.nlm.nih.gov/pubmed/16424112
[51]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. p. 921.
[52]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 930-934.
[53]Zhu, L., W. Wei, Y.-Q. Zheng, and X.-Y. Jia. “Effects and Mechanisms of Total Glucosides of Paeony on Joint Damage in Rat Collagen-Induced Arthritis.” Inflammation Research: Official Journal of the European Histamine Research Society … [et Al.] 54, no. 5 (May 2005): 211–20. doi:10.1007/s00011-005-1345-x. http://www.ncbi.nlm.nih.gov/pubmed/15953993
[54]Kim, In Deok, and Bae Jin Ha. “The Effects of Paeoniflorin on LPS-Induced Liver Inflammatory Reactions.” Archives of Pharmacal Research 33, no. 6 (June 2010): 959–66. doi:10.1007/s12272-010-0620-8. http://www.ncbi.nlm.nih.gov/pubmed/20607502
[55]Liu, Ling, Xiang-jun Qiu, Su-na He, Hui Yang, Deng Wang, and Xue-mei Yang. “[Effect of paeoniflorin on oxidative stress and energy metabolism in mice with lipopolysaccharide (LPS)-induced brain injury].” Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica 40, no. 14 (July 2015): 2871–75. http://www.ncbi.nlm.nih.gov/pubmed/26666042
[56]Wang, Qiang-Song, Teng Gao, Yuan-Lu Cui, Li-Na Gao, and Heng-Li Jiang. “Comparative Studies of Paeoniflorin and Albiflorin from Paeonia Lactiflora on Anti-Inflammatory Activities.” Pharmaceutical Biology 52, no. 9 (September 2014): 1189–95. doi:10.3109/13880209.2014.880490. http://www.ncbi.nlm.nih.gov/pubmed/24646307
[57]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. p. 932.
[58]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. http://www.itmonline.org/5organs/liver.htm.
[59]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 84-87.
[60]“Towards a Spirit at Peace – Chapter 8: Traditional Herb Formulas.” Accessed July 28, 2016. http://www.itmonline.org/shen/chap8.htm.
[61]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. p. 85.
[62]Wu, Jian, Yun-Yi Zhang, Li Guo, Hong Li, and Dao-Feng Chen. “Bupleurum Polysaccharides Attenuates Lipopolysaccharide-Induced Inflammation via Modulating Toll-like Receptor 4 Signaling.” PloS One 8, no. 10 (2013): e78051. doi:10.1371/journal.pone.0078051. http://www.ncbi.nlm.nih.gov/pubmed/24167596
[63]Wang, Xia, Qing Feng, Yong Xiao, and Ping Li. “Radix Bupleuri Ameliorates Depression by Increasing Nerve Growth Factor and Brain-Derived Neurotrophic Factor.” International Journal of Clinical and Experimental Medicine 8, no. 6 (2015): 9205–17. http://www.ncbi.nlm.nih.gov/pubmed/26309578
[64]Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. http://www.ncbi.nlm.nih.gov/pubmed/22562737
[65]Beau. “Psychospiritual Aspects of Herbal Medicine.” Accessed July 28, 2016. https://www.planetherbs.com/theory/psychospiritual-aspects-of-herbal-medicine.html.
[66]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/
[67]Beau. “Ashwagandha: Wonder Herb of India.” Accessed July 28, 2016. https://www.planetherbs.com/specific-herbs/ashwagandha-wonder-herb-of-india.html.
[68]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/
[69]Kaurav, Bhanu P. S., Manish M. Wanjari, Amol Chandekar, Nagendra Singh Chauhan, and Neeraj Upmanyu. “Influence of Withania Somnifera on Obsessive Compulsive Disorder in Mice.” Asian Pacific Journal of Tropical Medicine 5, no. 5 (May 2012): 380–84. doi:10.1016/S1995-7645(12)60063-7. http://www.ncbi.nlm.nih.gov/pubmed/22546655
[70]Sultana, N. “Hepatoprotective Role of Ashwagandha (Withania Somnifera) Root Extract against Gentamicin Induced Liver Damage in Rats.” Proceedings of The Physiological Society Proc 37th IUPS (2013). http://www.physoc.org/proceedings/abstract/Proc%2037th%20IUPSPCB197.
[71]Mwitari, Peter G., Peter A. Ayeka, Joyce Ondicho, Esther N. Matu, and Christine C. Bii. “Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania Somnifera, Warbugia Ugandensis, Prunus Africana and Plectrunthus Barbatus.” PLoS ONE 8, no. 6 (June 13, 2013). doi:10.1371/journal.pone.0065619. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681961/
[72]Bisht, Punum, and Vinita Rawat. “Antibacterial Activity of Withania Somnifera against Gram-Positive Isolates from Pus Samples.” Ayu 35, no. 3 (September 2014): 330–32. doi:10.4103/0974-8520.153757. http://www.ncbi.nlm.nih.gov/pubmed/25972723
[73]Alam, Nadia, Monzur Hossain, Md Abdul Mottalib, Siti Amrah Sulaiman, Siew Hua Gan, and Md Ibrahim Khalil. “Methanolic Extracts of Withania Somnifera Leaves, Fruits and Roots Possess Antioxidant Properties and Antibacterial Activities.” BMC Complementary and Alternative Medicine 12 (October 7, 2012): 175. doi:10.1186/1472-6882-12-175. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527235/
[74]Sharma, Arun, Ashutosh D. Deo, S. Tandel Riteshkumar, Thongam Ibemcha Chanu, and Arabinda Das. “Effect of Withania Somnifera (L. Dunal) Root as a Feed Additive on Immunological Parameters and Disease Resistance to Aeromonas Hydrophila in Labeo Rohita (Hamilton) Fingerlings.” Fish & Shellfish Immunology 29, no. 3 (September 2010): 508–12. doi:10.1016/j.fsi.2010.05.005. http://www.ncbi.nlm.nih.gov/pubmed/20580830
[75]Dikasso, Dawit, Eyassu Makonnen, Asfaw Debella, Dawit Abebe, Kelbessa Urga, Wallelign Makonnen, Daniel Melaku, Moges Kassa, and Mulugeta Guta. “Anti-Malarial Activity of Withania Somnifera L. Dunal Extracts in Mice.” Ethiopian Medical Journal 44, no. 3 (July 2006): 279–85. http://www.ncbi.nlm.nih.gov/pubmed/17447395
[76]Pandit, S., J. N. Cai, K. Y. Song, and J. G. Jeon. “Identification of Anti-Biofilm Components in Withania Somnifera and Their Effect on Virulence of Streptococcus Mutans Biofilms.” Journal of Applied Microbiology 119, no. 2 (August 2015): 571–81. doi:10.1111/jam.12851. http://www.ncbi.nlm.nih.gov/pubmed/25976122
[77]Grover, Abhinav, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey, and Durai Sundar. “Blocking Protein Kinase C Signaling Pathway: Mechanistic Insights into the Anti-Leishmanial Activity of Prospective Herbal Drugs from Withania Somnifera.” BMC Genomics 13 Suppl 7 (2012): S20. doi:10.1186/1471-2164-13-S7-S20. http://www.ncbi.nlm.nih.gov/pubmed/23281834
[78]Kim, Jae-Eun, Jun-Young Lee, Min-Jung Kang, Yu-Jin Jeong, Jin-A. Choi, Sang-Muk Oh, Kyung-Bok Lee, and Jong-Hwan Park. “Withaferin A Inhibits Helicobacter Pylori-Induced Production of IL-1β in Dendritic Cells by Regulating NF-κB and NLRP3 Inflammasome Activation.” Immune Network 15, no. 6 (December 2015): 269–77. doi:10.4110/in.2015.15.6.269. http://www.ncbi.nlm.nih.gov/pubmed/26770181
[79]Lee, Dae Hyung, In-Hye Lim, Eon-Gi Sung, Joo-Young Kim, In-Hwan Song, Yoon Ki Park, and Tae-Jin Lee. “Withaferin A Inhibits Matrix Metalloproteinase-9 Activity by Suppressing the Akt Signaling Pathway.” Oncology Reports 30, no. 2 (August 2013): 933–38. doi:10.3892/or.2013.2487. http://www.ncbi.nlm.nih.gov/pubmed/23708780
[80]Kataria, Hardeep, Sushil Kumar, Harshita Chaudhary, and Gurcharan Kaur. “Withania Somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.” Molecular Neurobiology 53, no. 6 (August 2016): 4143–58. doi:10.1007/s12035-015-9320-1. http://www.ncbi.nlm.nih.gov/pubmed/26208698 http://goodbyelyme.com/stop_bartonella_rage_ocd
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..... ,,And while flea-infested cats are known for transmitting Bartonella henselae, here’s a case Breitschwerdt published involving an 11-year old Ottawa girl who presumably got a Bartonella henselae infection after nursing an oozing abscess in an ill dog the family adopted from a shelter. The dog had been certified healthy. The child suddenly developed headaches, difficulty walking and weakness on her left side. According to the case study, “A few weeks later, the girl developed flu-like symptoms followed by progressive neurological abnormalities.” Three years after the exposure, “the patient experienced frequent headaches, chest pain, visual and auditory hallucinations, anxiety, ocular floaters, severe depression, and fatigue. Additional episodes of partial paralysis occurred.” Eleven years later, after seeing a physician in Vancouver, Canada (2,700 miles west of Ottawa) the child finally received a diagnosis and treatment.
My daughter’s Bartonella infection came from two simultaneous tick bites, and like many people infected with Bartonella, she developed a distinctive red-streaked rash. She suffered from headaches, dizziness and neurological symptoms, consistent with neurobartonellosis. She spent more time in bed than out. Four years after the initial bites (and numerous doctor visits) a psychiatrist diagnosed Bartonella when he saw her rashes,,.....................
http://www.phillyvoice.com/bartonella-infection-steals-life-long-it-kills/
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